SCALABLE IN SILICO SIMULATION OF TRANSDERMAL DRUG PERMEABILITY: APPLICATION OF BIOISIM PLATFORM


PSENEN influences the progression of renal clear cell carcinoma by regulating the immune microenvironment and oxidative phosphorylation

Background Presenilin enhancer gamma-secretase subunit (PSENEN), the straight Detergent Drawer Top target of metformin, is highly expressed in several cancers.The role of PSENEN in kidney renal clear cell carcinoma (KIRC) has not been reported.Methods PSENEN expression in KIRC specimens was investigated in The Cancer Genome Atlas (TCGA) and Gene Ex

read more

The slippery paths of commemoration and Heritage tourism: the Netherlands, Ghana, and the rediscovery of Atlantic slavery

Reflects upon the commemoration of the Atlantic slave trade and American slavery.Author describes how the slave trade and slavery was recently "rediscovered", as a part of Dutch history, and he compares this to the attention to this history in other European countries once engaging in slavery.He argues that despite the fact that the history of the

read more

Skeletal Transformations and the Origin of Baleen Whales (Mammalia, Cetacea, Mysticeti): A Study on Evolutionary Patterns

A review of the morphological patterns exhibited by all the main radiations of mysticete (baleen whale) cetaceans provided a broad assessment of the fundamental morphological transformations that occurred in the transition to the Mysticeti clade.Skull and postcranial characters were illustrated, described and compared, and their distribution was ma

read more